3018866
print

Dermatomyositis and Polymyositis Panel

COMBI PAN2

Ordering Recommendation

May be useful for the evaluation of patients with progressive proximal muscle weakness and/or cutaneous manifestations suggestive of dermatomyositis and/or associated connective tissue disease.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer two 1 mL serum aliquots to ARUP standard transport tubes. (Min: 0.5 mL/aliquot)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Hemolyzed, hyperlipemic, icteric, heat-treated, or contaminated specimens

Remarks
Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month

Methodology

Qualitative Immunoprecipitation / Semi-Quantitative Multiplex Bead Assay / Qualitative Immunoblot / Semi-Quantitative Indirect Fluorescent Antibody (IFA)

Performed

Sun-Sat

Reported

7-18 days

Reference Interval

Test Number
 Components
 Reference Interval
  Zo (phenylalanyl-tRNA synthetase) Ab Negative
  Ks (asparaginyl-tRNA synthetase) Ab Negative
  Ha (tyrosyl-tRNA synthetase) Ab Negative
  TIF-1 gamma (155 kDa) Ab Negative
  NXP2 (Nuclear matrix protein-2) Ab Negative
  MDA5 (CADM-140) Ab Negative
  SAE1 (SUMO activating enzyme) Ab Negative
  Antinuclear Antibody (ANA), HEp-2, IgG Less than 1:80
  OJ (isoleucyl-tRNA synthetase) Antibody Negative
  SRP (Signal Recognition Particle) Ab Negative
  EJ (glycyl-tRNA synthetase) Antibody Negative
  P155/140 Antibody Negative
  PL-12 (alanyl-tRNA synthetase) Antibody Negative
  PL-7 (threonyl-tRNA synthetase) Antibody Negative
  Mi-2 (nuclear helicase protein) Antibody Negative
  Jo-1 (Histidyl-tRNA Synthetase) Ab, IgG 40 AU/mL or less

Interpretive Data

Refer to report.


Component Interpretation
Jo-1 Antibody, IgG 29 AU/mL or less: Negative
30-40 AU/mL: Equivocal
41 AU/mL or greater: Positive

Compliance Category

Laboratory Developed Test (LDT)

Note

Antibodies:  PL-7, PL12, EJ, OJ, SRP, Jo-1, Mi-2, P155/140, SAE1, MDA5, NXP2, TIF1-gamma, ANA, Ha, Ks, Zo

Hotline History

N/A

CPT Codes

83516 x7; 84182 x7; 86235; 86039

Are you an ARUP Client? Click here for your pricing.

Components

Component Test Code* Component Chart Name LOINC
0099592 Jo-1 (Histidyl-tRNA Synthetase) Ab, IgG 33571-1
2010852 Mi-2 (nuclear helicase protein) Antibody 18485-3
2010853 PL-7 (threonyl-tRNA synthetase) Antibody 33772-5
2010854 PL-12 (alanyl-tRNA synthetase) Antibody 33771-7
2010855 P155/140 Antibody 8061-4
2010856 EJ (glycyl-tRNA synthetase) Antibody 45149-2
2010859 SRP (Signal Recognition Particle) Ab 33921-8
2010860 OJ (isoleucyl-tRNA synthetase) Antibody 45152-6
2013997 Myositis Interpretive Information 48767-8
3000090 Antinuclear Antibody (ANA), HEp-2, IgG 21424-7
3000096 ANA Interpretive Comment 49311-4
3001786 SAE1 (SUMO activating enzyme) Ab 82440-9
3001787 MDA5 (CADM-140) Ab 82424-3
3001788 NXP2 (Nuclear matrix protein-2) Ab 82426-8
3001789 TIF-1 gamma (155 kDa) Ab 82448-2
3017636 Ha (tyrosyl-tRNA synthetase) Ab
3017637 Ks (asparaginyl-tRNA synthetase) Ab
3017638 Zo (phenylalanyl-tRNA synthetase) Ab
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Dermatomyositis and Polymyositis Panel